Computational investigation of the anticancer potential of Sorghum bicolor and Setaria italica phytochemicals against dihydrofolate reductase (DHFR) enzyme

Table 4 In silico pharmacokinetics of ligands using Swiss ADME

Properties	Log S(ESOL)	GI absorption	BBB permeant	P-gp substrate	CYP1A2	CYP3A4	CYP2C19	Bioavailability score
1BOZ
Caffeic acid 689043	Very Soluble	High	No	No	No	No	No	0.56
Ferulic acid 445858	Soluble	High	Yes	No	No	No	No	0.85
Hesperetic Acid 736186	Soluble	High	Yes	No	No	No	No	0.85
1OHK
Stigmasterol 5280794	Poorly Soluble	Low	No	No	No	No	No	0.55
Cis-p-Coumaric acid1549106	Soluble	High	Yes	No	No	No	No	0.85
Luteolinidin 441701	Soluble	High	No	Yes	Yes	No	No	0.55
Standard drugs
Capecitabine 60953	Soluble	High	No	Yes	No	No	No	0.55
Flutamide 3397	Soluble	High	Yes	No	Yes	No	Yes	0.55

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